So I've talked about Inochi2D, I'm making 2 apps to accompany the spec itself.

Inochi Creator and Inochi Session.
Inochi Creator is a tool that allows you to rig layered 2D art in to a 2D puppet that can move, animation is done through 3D transformation and deformation of vertices you specify in the editor.
https://github.com/Inochi2D/inochi-creator

Inochi Session will be a tool to allow you to stream using your 2D puppet.
https://github.com/Inochi2D/inochi-session (nothing here yet)